منابع مشابه
What is molecular diversity?
It is my great pleasure to serve as the new Editor-inChief of Molecular Diversity. The first volume of this Journal was published in 1995 when I was founding MDPI. At that time, the topic of molecular diversity, namely combinatorial synthesis and high-throughput synthesis and screening, was rapidly developing. The launch of Molecular Diversity, under the Editorship of Richard A. Houghten, Walte...
متن کاملManaging molecular diversity.
The present work provides an overview of the different methods used in molecular diversity analysis. Issues like identifying voids in proprietary databases, reducing the number of redundancies present in databases, or designing focused libraries by grouping compounds similar to a template with the aim to fine tune its properties, are potent diversity analysis tools that may be used to optimize ...
متن کاملhydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction
hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...
The measurement of molecular diversity by receptor site interaction simulation
The assembly of large compound libraries for the purpose of screening against various receptor targets to identify chemical leads for drug discovery programs has created a need for methods to measure the molecular diversity of such libraries. The method described here, for which we propose the acronym RESIS (for Receptor Site Interaction Simulation), relates directly to this use. A database is ...
متن کاملAssessment of Genetic Diversity in Podophyllum peltatum by Molecular Markers*
The quality and quantity of medicinal plants are serious issues for the pharmaceutical and dietary supplement industries. Traditionally, this material has been harvested from the wild, and while cultivation procedures have been developed for supplements such as St. John’s Wort, this is still the general method employed for the majority of medicinal plants. Increasing public demand for these pro...
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/457153a